key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
Note: The feedback section of this quiz works only with Internet Explorer, and not with Firefox.

Aronoff

Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?
How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: July 03, 2008 (J03)
J03 Statins spur glial progenitor cells to develop into oligodendrocytes.
J03 Pfizer will no longer work directly with for-profit CME companies.
J03 FDA panel recommends that all new diabetes drugs be screened for cardiovascular risk.
J02 New orally active, broad-spectrum angiogenesis inhibitor may be useful against many cancers.
J28 Bill to approve pathway for FDA approvals of biosimilars advocated as saving billions of dollars.
J26 Two siRNA in the Phase I/II pipeline for kidney disease, one for delayed graft function, the other for AKI
J24 Take your meds and have a chance at winning the lottery.
J23 Rapamycin may impact retardation in tuberous sclerosis and might be useful in treating autism.
J19 FDA cautions about increased mortality in elderly patients with dementia who had been treated with antipsychotic drugs
J18 Computer generated warfarin dosing as effective as dosing by expert prescribers.
J13 FDA and EMEA to consider biomarkers of renal injury in animal studies evaluating renal safety of new drugs.
J12 XBP1, stimulated by a high-carb diet, may be a new target for treatment of dyslipidemias.
J12 FDA approves generic form of ramipril made by Lupin pharmaceuticals.
J11 CMS gives researchers access to parts of the Medicare prescription drug benefit database.
J05 FDA: More on the ongoing review of TNF-blockers and cancer risk.
Industry Advances Emphasis
archive
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis Hypertens (2008)
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
ESRD PHARMACOKINETICS
Drug Dosing in Renal Failure
(link now works)
HDCN Topic Pages
Interstitial Nephritis
Adverse drug effects
OTHER LINKS
Australian Prescriber
Drug Facts and Comparisons
GSM Clin Pharm
Manufacturer Directory
MedPharm Pharmacology Links
Nephrology Pharm Assoc
Pharmacy Times Links
PowerPak Pharm CE
Renal Pharmacist Network
U.S. Pharmacopoeia

Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.