Lewis  

Emerging New Agents in Diabetic Kidney Disease

(Julia Lewis, MD. ASN Renal Week 2005). There are at least five new approaches beyond ACE inibitors to diabetic nephropathy: Aldosterone blockers, ruboxistaurin, prifenidone, COX-2 inhibition, and sulodexide. What is the rationale for each of these interventions and what do the early pilot studies show?
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Williams  

Coronary Angioplasty and Stenting: Indications and Results

(Mark Williams, MD. ASN Renal Week 2005). In diabetics mortality with CAD is increased and classically they do worse with percutaneous interventions due to restenosis rathen than with bypass surgery. Is this also true for diabetic patients with CKD? To what extent has the picture changed with the use of drug-eluting stents? What are the anti-thrombotic strategies that can be used in such patients after stenting and how do these influence outcomes?
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McGill

The Role of Glycemic Control and How Best to Achieve it

(ASN Renal Week Clinical Nephrology Conference November, 2005, Philadelphia, PA)
To what extent does HbA1c predict adverse events in diabetics? In non-diabetics? How low must one go to avoid the increased CV risk? Is <7.0% low enough? What did follow-up from the DCCT/EDIC trials show? What is the benefit of multiple risk factor reduction (Steno-2 Trial)? What is the modern approach to glucose control, including use of metformin (in non-CKD), alpha-glucosidase inhibitors, incretins, secretagogues, and thiazolidinediones? What are practical points regarding use of PPAR-gamma agonists, exenatide? What are the benefits of the thiazolidinediones in terms of lipids, prevention of restenosis, and reduction of albuminuria? (more...)

Updated: July 03, 2008 (J03)
J03 FDA panel recommends that all new diabetes drugs be screened for cardiovascular risk.
J01 Doxycycline-inhibitable protease activity increased in SHR rats; this also may explain various aspects of metabolic syndrome.
J26 Fructose, but not glucose, increases visceral adipose tissue and triglycerides, and lower insulin sensitivity.
J25 Obesity drug rimonabant approved for NHS use in England and Wales.
J18 HHV-8 herpes virus linked to ketosis-prone type 2 diabetes in Africa.
J17 Big breakfast diet more effective than low-carb diet in maintaining weight loss.
J17 Diabetes doubles the risk of hearing loss.
J16 Studies with fat cells suggest that resveratrol may help combat obesity.
J11 FDA: Concern about potential cancer risk in users of Regranex (becaplermin) gel (used to help heal foot ulcers in diabetics).
J10 Rosiglitazone may slow progression of diabetic eye disease.
J10 Large Australian RCT specifically shows that lowering HbA1C in diabetics to a 6.5% target protects the kidney.
J10 NEJM: Full text of ADVANCE trial, which showed a benefit of intensive glucose control (HbA1C to 6.5%)
J09 NEJM: Glycemic control in the ADVANCE vs. ACCORD trials (editorial)
J09 NEJM: ACCORD trial results published (full text): Intensive blood glucose lowering in diabetes may worsen outcomes.
J09 VA diabetes trial reports at ADA. Lowering HbA1c below 7% associated with a trend for improved CV outcomes.
General Advances Emphasis
archive
Emerging New Agents in Diabetic Kidney Disease (Lewis) ASN 2005 Renal Week
Coronary Angioplasty and Stenting: Indications and Results (Williams) ASN 2005 Renal Week
Disease Management Actually Works in Dialysis Patients (Sands) RRI 2006, Part 2 (handouts)
Optimizing the Total Care of the Diabetic Patient with Kidney Disease - Lipids (Molitch) ASN Renal Week 2005
Optimizing the Total Care of the Diabetic with Kidney Disease (McGill, Kaplan, Molitch, Williams) ASN Renal Week 2005 (audiofiles)
Obesity and the Kidney (Lord, Scherer, Fliser) ASN Renal Week 2005 (audiofiles)
Novel Pathways for Prevention of Diabetes and Obesity-Related Renal and Vascular Disease (Cooper, Danesh) ASN Renal Week 2005 (audiofiles)
Newer Approaches to Diabetic Kidney Disease (Hollenberg, Lewis, Pavlakis) ASN Renal Week 2005 (audiofiles)
Diabetes and Dialysis (Oreopoulos, Friedman, Dasgupta, Kopple) ADC 2005 (audiofiles)
The Metabolic Syndrome and Kidney Disease: An Important Complication of Systemic Vascular Disease (Tuttle) ASN 2004
New Insights in the Pathogenesis of Uric Acid Nephrolithiasis (Sakhaee) ASN 2004

Debate: Weight loss and blood pressure control (Pro) vs. Dietary therapy for obesity: an emperor with no clothes (Con) Hypertens (Jun 2008)
Large artery stiffening with weight gain in humans: role of visceral fat accumulation Hypertens (Jun 2008)
Screening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (Jun 2008)
Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care Diabet Care (May 2008)
Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (May 2008)
Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation Diabet Care (Apr 2008)
Hyperglycemia and acute coronary syndrome: A Scientific Statement From the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation (Mar 2008)
Adiponectin, cardiovascular function, and hypertension Hypertens (Jan 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes (Briggs J) NCPN Jun 07
Hypomagnesemia in patients with type 2 diabetes CJASN 03-07
Hypomagnesemia in patients with type 2 diabetes (Pham et al) CJASN (03-2007)
KDOQI Clinical Practice Guidelines and CPRs (2006 update) for Treatment of Diabetes and CKD AJKD (Feb 07)
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Advanced glycation end products and nephrotoxicity of high-protein diets (Uribarri, Tuttle) CJASN 11-06
ACE2: A new target for prevention of diabetic nephropathy? (Ingelfinger JR, commenting on an article by Batlle's group) JASN 11-06
Angiotensin-converting enzyme-2 (ACE-2) - a new player in the genesis of glomerular injury? (Comment by Ritz on paper by Oudit et al) JASN 10-06
Management of dyslipidemias in patients with diabetes and chronic kidney disease (Molitch). CJASN 09-06
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